Analyses and predictions of ultrasound interactions with model biomembrane systems via two-state transition model
Tata, Darayash Burjor
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https://hdl.handle.net/2142/23330
Description
Title
Analyses and predictions of ultrasound interactions with model biomembrane systems via two-state transition model
Author(s)
Tata, Darayash Burjor
Issue Date
1991
Doctoral Committee Chair(s)
Dunn, Floyd
Department of Study
Biophysics and Computational Biology
Discipline
Biophysics and Computational Biology
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Chemistry, Physical
Engineering, Biomedical
Physics, Acoustics
Language
eng
Abstract
Low intensity ultrasound (approximately 10$\sp{-6}$ W/cm$\sp2$) in the frequency range of 0.5 MHz to 5.0 MHz was employed to investigate biomembrane structural relaxation kinetics via absorption and velocity dispersion spectroscopy. The multilamellar vesicles utilized in this investigation were either composed of pure phospholipids or mixtures of phospholipids and small molar fractions of protein gramicidin. The experimental findings reveal enhanced ultrasound interactions near to the lipid phase transition temperature. The enhanced ultrasound absorption spectra closely resemble single relaxation spectra, suggesting that the membrane constituents undergo a simple two-state transition. The temperature dependence of the relaxation frequency is followed with the combined aid of the absorption and velocity dispersion spectrum. Thermodynamic and electrical capacitor two-state transition models are developed to help describe the observed phenomena and to predict to a reasonable degree of accuracy the enhanced findings promoted by ultrasound.
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