The role of lymphatic vessels draining the wall of aorta and coronary arteries in the pathogenesis of atherosclerosis induced by cholesterol/casein diet
Wu, Maoxin
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Permalink
https://hdl.handle.net/2142/21783
Description
Title
The role of lymphatic vessels draining the wall of aorta and coronary arteries in the pathogenesis of atherosclerosis induced by cholesterol/casein diet
Author(s)
Wu, Maoxin
Issue Date
1995
Doctoral Committee Chair(s)
Nishida, Toshiro
Department of Study
Nutritional Sciences
Discipline
Nutritional Sciences
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Biology, Animal Physiology
Health Sciences, Nutrition
Health Sciences, Pathology
Language
eng
Abstract
It has been suggested that inadequate lymphatic drainage contributes to the pathogenesis of atherosclerosis. However, there are very few reports to support this hypothesis. This work was designed to study the role of lymphatic vessels draining the wall of the aorta and coronary arteries in the pathogenesis of atherosclerosis. Twenty four male New Zealand White rabbits were randomly divided into 3 groups: 8 fed a control diet, 8 fed a 5% cholesterol diet and 8 fed a 1% cholesterol diet. The animals were sacrificed at weekly intervals from 1 to 10 weeks. Total serum cholesterol, LDL and HDL cholesterol concentrations were determined prior to the onset of the experiment and immediately preceding sacrifice. The animals were perfusion fixed with Karnovski's solution. Tissue samples were obtained from the arch, thoracic and abdominal areas of the aortae and left and right of coronary arteries. The sections of the tissue samples were examined for the presence of atherosclerotic lesions in the intima and presumptive lymphatic vessels in the adventitia of the arteries. The National Institute of Health (NIH) Image System was used for the quantitative morphometric analyses. The atherosclerotic lesions appeared earlier and were more extensive in the arch than in the abdominal part of the aorta. The frequency of plaques without underlying lymphatics was 91.8% and the frequency of lymphatics without overlying plaques was 97.1%. There was an inverse relationship between the area of plaque and the area of associated draining lymphatics in the aortae of the experimental animals. A similar relationship was found with the coronary arteries in that the frequency of plaques in the left and right arteries without lymphatics was 78.0% and 68.8% respectively and the frequency of lymphatics without plaques in the left and right coronary vessels was 67.5% and 57.0% respectively. Area density of plaques in the arteries without lymphatic drainage was greater than that with lymphatic drainage. These results suggest that lymphatic vessels may play an important role in the pathogenesis of atherosclerosis.
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