Phosphorus-31 nuclear magnetic resonance spectroscopy of human uterus and placenta
Raman, Jyothi
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https://hdl.handle.net/2142/21691
Description
Title
Phosphorus-31 nuclear magnetic resonance spectroscopy of human uterus and placenta
Author(s)
Raman, Jyothi
Issue Date
1991
Doctoral Committee Chair(s)
Dawson, M. Joan
Department of Study
Biophysics and Computational Biology
Discipline
Biophysics
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Health Sciences, Obstetrics and Gynecology
Health Sciences, Radiology
Biophysics, Medical
Language
eng
Abstract
This thesis aims to demonstrate the usefulness of Nuclear Magnetic Resonance Spectroscopy in understanding normal human placental and uterine metabolism as well as its application in the study of gestational and gynecological disorders. We have used phosphorus-31 NMR spectroscopy on isolated samples of placenta and uterus (myometrium and endometrium). Our studies have revealed interesting correlations between spectral characteristics and the type of tissue studied, normal and abnormal.
The $\sp{31}$P spectrum of placenta changes as it matures with increasing gestational age. In addition, complications of pregnancy, including intrauterine growth-retardation and hydatidiform mole, are associated with significant changes in the placental spectrum. Absolute volume of intracellular water and intracellular concentrations of normal placental phosphorus metabolites were obtained.
The effects of pregnancy are manifested in the NMR spectra of normal pregnant myometria. Experiments on nonpregnant diseased uterus have revealed presence of disease in histologically normal tissue obtained close to a uterine lesion. We have also demonstrated feasibility and cost-effectiveness of evaluation of endometrial biopsies by NMR prior to histopathological examination.
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