University of Illinois Urbana-Champaign

The biosynthesis of brominated tyrosine metabolites by Aplysina fistularis

Carney, John Ray

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https://hdl.handle.net/2142/20218

Description

Title
The biosynthesis of brominated tyrosine metabolites by Aplysina fistularis
Author(s)
Carney, John Ray
Issue Date
1990
Doctoral Committee Chair(s)
Rinehart, Kenneth L., Jr.
Department of Study
Chemistry
Discipline
Chemistry
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
  • Chemistry, Organic
  • Agriculture, Fisheries and Aquaculture
Language
eng
Abstract
The biosynthesis of brominated tyrosine metabolites by the marine sponge Aplysina fistularis was investigated. ($U$-$\sp{14}$C) -L-Tyrosine, ($U$-$\sp{14}$C) -L-3-bromotyrosine, and ($U$-$\sp{14}$) -3,5-dibromotyrosine were incorporated into both dibromoverongiaquinol and aeroplysinin-1, and (methyl-$\sp{14}$C) methionine was specifically incorporated into the O-methyl group of aeroplysinin-1. (Methyl-$\sp{14}$C) -O-methyltyrosine and (methyl-$\sp{14}$C) -3,5-dibromo-O-methyltyrosine and several putative nitrile precursors were not significantly incorporated into aeroplysinin-1.
Type of Resource
text
Permalink
http://hdl.handle.net/2142/20218
Copyright and License Information
Copyright 1990 Carney, John Ray

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