University of Illinois Urbana-Champaign

The intraorgan lymphatic system of the rat left ventricle in normalcy and aging

Doyle, Michael David

This item is only available for download by members of the University of Illinois community. Students, faculty, and staff at the U of I may log in with your NetID and password to view the item. If you are trying to access an Illinois-restricted dissertation or thesis, you can request a copy through your library's Inter-Library Loan office or purchase a copy directly from ProQuest.

Permalink

https://hdl.handle.net/2142/18927

Description

Title
The intraorgan lymphatic system of the rat left ventricle in normalcy and aging
Author(s)
Doyle, Michael David
Issue Date
1991
Doctoral Committee Chair(s)
O'Morchoe, Patricia J.
Discipline
Biology
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
  • Biology, Anatomy
  • Biology, Cell
  • Computer Science
Language
eng
Abstract
Intracardiac lymphatic vessels of the rat heart left ventricle were studied quantitatively at the ultrastructural level in order to establish baseline morphometric data and also to assess age-related variability in the accepted visible macromolecular transport pathways. Lymphatic vessels were found in both epicardial and myocardial areas. No endocardial lymphatics were found. Both intercellular and transendothelial visible macromolecular transport pathways were examined in 3, 6, 12, 18, and 28 month old animals. No age-related variations were seen in measurements of intercellular transport pathways, represented by dilatations and channels between adjacent endothelial cells. Transendothelial pathways, represented by cytoplasmic vesicles, showed many significant variations in quantitative measurements among the 5 age groups studied. These changes included an increase with aging in the thickness of myocardial lymphatic endothelial cells, increases and decreases in the mean diameters of lymphatic endothelial vesicles, and a decrease between 6 and 12 month animals in the volume density of lymphatic cytoplasmic vesicles. These age-related variations may have a direct relationship to similar variations in macromolecular transport capacity.
Type of Resource
text
Permalink
http://hdl.handle.net/2142/18927
Copyright and License Information
Copyright 1991 Doyle, Michael David

Owning Collections

Graduate Dissertations and Theses at Illinois PRIMARY
Graduate Theses and Dissertations at Illinois