University of Illinois Urbana-Champaign

The effects of alterations in internal Ca levels on cat small intestinal slow waves

Mangel, Allen W.

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Mangel_Allen.pdf

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https://hdl.handle.net/2142/18820

Description

Title
The effects of alterations in internal Ca levels on cat small intestinal slow waves
Author(s)
Mangel, Allen W.
Issue Date
1980
Director of Research (if dissertation) or Advisor (if thesis)
Connor, John A.
Doctoral Committee Chair(s)
Connor, John A.
Committee Member(s)
  • Arntzen, Charles J.
  • Sherwood, O. David
  • Prosser, C. Ladd
  • Curtis, Brian A.
Department of Study
Physiology
Discipline
Physiology
Degree Name
Ph.D.
Degree Level
Dissertation
Date of Ingest
2011-04-13T17:37:41Z
Keyword(s)
  • Physiology
  • Cats
  • Animals
Language
en
Abstract
Control of slow wave frequency in cat small intestinal muscle was investigated with microelectrodes. Exposure of intact muscle or isolated longitudinal muscle to low Ca('2+) saline decreased slow wave frequency with less than a 6 mV change in resting potential. This frequency decline was characterized by a prolongation of the diastolic phase of the slow wave. Raising Ca(,0)('2+) to 2-3 times normal increased slow wave frequency. At Ca(,0)('2+) greater than 4 times normal, the slow wave frequency again decreased. However, this decrease in frequency was characterized by a prolongation of the systolic phase of the waveform. Application of Ca conductance blockers (Co('2+), Mn('2+), D600, verapamil), increasing Mg(,0)('2+) or increasing internal pH decreased slow wave frequency by a prolongation of the diastolic region of the slow wave. Addition of db-cAMP to Krebs saline made hypertonic with sucrose or decreasing internal pH increased slow wave frequency. These results indicate a relationship between internal Ca('2+) and the pacemaker of slow wave frequency. A scheme is proposed to explain that relationship.
Type of Resource
text
Permalink
http://hdl.handle.net/2142/18820
Copyright and License Information
Copyright 1980 Allen Wayne Mangel

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