Catheter for endoscopic magnetomotive optical coherence tomography

Li, Di

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https://hdl.handle.net/2142/18621 Copy

Description

Title

Catheter for endoscopic magnetomotive optical coherence tomography

Author(s)

Li, Di

Issue Date

2011-01-21T22:52:04Z

Director of Research (if dissertation) or Advisor (if thesis)

Boppart, Stephen A.

Department of Study

Nuclear, Plasma, & Rad Engr

Discipline

Nuclear Engineering

Degree Granting Institution

University of Illinois at Urbana-Champaign

Degree Name

M.S.

Degree Level

Thesis

Keyword(s)

• Optical Coherence Tomography
• Catheter
• Magnetomotive optical coherence tomography (OCT)

Abstract

In this thesis, a catheter design is proposed for endoscopic magnetomotive optical coherence tomography (MM-OCT). Magnetomotive optical coherence tomography is a novel technique which uses targeted magnetic contrast agents for contrast enhancement of OCT imaging. In MM-OCT, microspheres and magnetic nanoparticles (MNPs) are introduced into tissue and an electromagnet is used to generate a small modulated magnetic field within the tissue during OCT imaging. The magnetic field will introduce mechanical displacement of the MNPs, which can be detected, and the MM-OCT signal can be measured. The current bench-top set-up does not allow for in vivo MM-OCT imaging because the magnetic field is provide by a solenoid with an outer diameter of ~18 mm and an axial thickness of ~9 mm. A magnetomotive catheter design was developed by wrapping small coil around the distal end of a standard OCT catheter to combine the novel MM-OCT technology and catheter-based OCT. The coil has a small size while providing a local magnetic field for MM-OCT imaging. This magnetomotive catheter will enable investigations of in vivo magnetomotive contrast enhancement from the magnetic agents used in MM-OCT imaging.

Graduation Semester

2010-12

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http://hdl.handle.net/2142/18621

Copyright and License Information

Copyright 2010 Di Li

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