Vibrational characteristics of brain magnetic resonance elastography
Johnson, Curtis L.
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https://hdl.handle.net/2142/16225
Description
Title
Vibrational characteristics of brain magnetic resonance elastography
Author(s)
Johnson, Curtis L.
Issue Date
2010-05-19T18:41:09Z
Director of Research (if dissertation) or Advisor (if thesis)
Georgiadis, John G.
Department of Study
Mechanical Sci & Engineering
Discipline
Mechanical Engineering
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
M.S.
Degree Level
Thesis
Keyword(s)
Magnetic resonance imaging
Magnetic resonance elastography
Tissue stiffness
Brain
Abstract
This thesis aims to investigate vibrational characteristics of magnetic resonance elastography (MRE) of the brain. MRE is a promising, non-invasive methodology for the mapping of shear stiffness of the brain. A mechanical actuator shakes the brain and generates shear waves, which are then imaged with a special MRI sequence sensitive to sub-millimeter displacements. This research focuses on exploring the profile of vibrations utilized in brain elastography from the standpoint of ultimately investigating nonlinear behavior of the tissue. The first objective seeks to demonstrate the effects of encoding off-frequency vibrations using standard MRE methodologies. Vibrations of this nature can arise from nonlinearities in the system and contaminate the results of the measurement. The second objective is to probe nonlinearity in the dynamic brain system using MRE. A non-parametric decomposition technique, novel to the MRE field, is introduced and investigated.
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