Single molecule study of weak and transient biological interactions
Cisse, Ibrahim
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https://hdl.handle.net/2142/14744
Description
Title
Single molecule study of weak and transient biological interactions
Author(s)
Cisse, Ibrahim
Issue Date
2010-01-06T17:49:07Z
Director of Research (if dissertation) or Advisor (if thesis)
Ha, Taekjip
Doctoral Committee Chair(s)
Chemla, Yann R.
Committee Member(s)
Goldenfeld, Nigel D.
Stack, John D.
Department of Study
Physics
Discipline
Physics
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Single Molecule
Weak Interactions
Transient Interactions
Protein-DNA Interactions
DNA-DNA Interactions
RNA-RNA Interactions
Protein-Protein Interactions
Abstract
Over the past decade, major breakthroughs were led in molecular biology with techniques allowing the study of dynamics at the resolution of an individual molecule. We have been expanding this capability by adapting porous vesicle encapsulation to single molecule fluorescence techniques. The porous vesicle encapsulation method allows the study of individual macromolecules in a biofriendly, cell-like environment, where the chemical condition can be changed and the desired reactions are triggered at will. Specifically, this adaptation now allows the study of weakly and transiently interacting biomolecules at the single-molecule resolution. Here we present unique interactions between proteins and nucleic acids which were previously unattainable with conventional single molecule techniques.
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