A Framework for Knowledge Discovery from Sparse, High-Dimensional Medical Datasets

Ramachandran, Chandrasekar

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https://hdl.handle.net/2142/14710 Copy

Description

Title

A Framework for Knowledge Discovery from Sparse, High-Dimensional Medical Datasets

Author(s)

Ramachandran, Chandrasekar

Issue Date

2010-01-06T16:40:06Z

Director of Research (if dissertation) or Advisor (if thesis)

Han, Jiawei

Doctoral Committee Chair(s)

Han, Jiawei

Department of Study

Computer Science

Discipline

Computer Science

Degree Granting Institution

University of Illinois at Urbana-Champaign

Degree Name

M.S.

Degree Level

Thesis

Keyword(s)

• islet cell transplants
• medical data mining
• dimensionality reduction
• association rule mining

Abstract

In this work, we describe a comprehensive framework for knowledge discovery from medical records called SDM-Miner. The records are created before, during and after pancreatic islet cell transplantation1 on a group of diabetic patients. The knowledge discovery focuses on selecting the most relevant variables for predicting the outcome of islet cell transplants temporally, and supporting the medical understanding of the variable relationships that would lead to insulin-free outcome of a transplant with machine learning models. The challenges of knowledge discovery lie in the temporally sparse nature of medical records and the large number of variables which make the traditional statistical analyses ineffective. Our approach to overcome the challenges is to combine data-driven computationally intensive modeling with statistical modeling. The framework incorporates this approach during three phases of knowledge discovery including (1) statistical data-preprocessing, (2) pattern search based dimensionality reduction, and (3) association rule based and conditional probability based data-driven modeling. We evaluate the framework by cross validating the models (of machine learning) using prediction errors and uncertainty of rule discovery. In order to demonstrate the novelty of the framework and the improved performance in knowledge discovery, we report results using real and synthetic datasets. Experimental results on synthetic data act as a sanity check in order to verify the effectiveness of our models in the absence of standard test results. The evaluation results show that our framework led to smaller mean error with the decreasing number of variable samples, higher robustness to Gaussian noise, and higher confidence and support of association rules than the previous methods. Furthermore, we evaluate our proposed technique using existing machine learning algorithms using the Weka toolkit and show the improved performance of our work as compared to previous approaches.

Graduation Semester

2009-12

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http://hdl.handle.net/2142/14710

Copyright and License Information

Copyright 2009 Chandrasekar Ramachandran

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