DNA Sequencing; Solid state Nanopore; Mos2; hBN; Molecular Dynamics
Abstract
Solid-state nanopores are excellent candidates for biomolecule sensing. However, difficulties remain in accurate sensing and sequencing, due to the noise generated from the translocation of such molecules through these nanopores. This work investigates the feasibility of a stacked solid-state nanopore structure consisting of semiconducting Molybdenum Disulfide (MoS2) monolayers and insulating Hexagonal Boron Nitride monolayers. The structure is modeled using Molecular Dynamics with single-strand DNA homopolymers translocating through the nanopore, from which the trans-conducting current is calculated. Our calculation demonstrates a reduction in the overall conformational motion of the homopolymers as they translocate through successive layers. Finally, we show that better signal can be achieved when signals generated from different layers are aligned using time-lagged cross-correlation.
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