RICH CONFORMATIONAL LANDSCAPES OF MACROCYCLIC MUSKS BY BROADBAND ROTATIONAL SPECTROSCOPY: AN INSIGHT INTO THE MUSK SCENT MYSTERY

Sanz, M. Eugenia

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https://hdl.handle.net/2142/122718 Copy

Description

Title

RICH CONFORMATIONAL LANDSCAPES OF MACROCYCLIC MUSKS BY BROADBAND ROTATIONAL SPECTROSCOPY: AN INSIGHT INTO THE MUSK SCENT MYSTERY

Author(s)

Sanz, M. Eugenia

Contributor(s)

• Loru, Donatella
• Burevschi, Ecaterina

Issue Date

2023-06-21

Keyword(s)

Rotational structure/frequencies

Abstract

Musk odorants are key compounds in perfumery due to their warm, sensual and animalistic scent, and their fixative properties. Natural musks are macrocycles typically containing ketone or lactone functional groups. However, despite their widespread use, the molecular features conductive to musk smell are not clear. No experimental information is available on the conformations of macrocyclic musks and the structural elements determining their binding to odorant receptors. Here we present the study of several prototypical macrocyclic musks using broadband microwave spectroscopy in combination with quantum chemistry calculations. Their conformations have been identified and compared to start understanding the molecular determinants that lead to musk odour.

Publisher

International Symposium on Molecular Spectroscopy

Type of Resource

Text

Language

eng

Handle URL

https://hdl.handle.net/2142/122718

DOI

https://doi.org/10.15278/isms.2023.7351

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