University of Illinois Urbana-Champaign

CIVP SPECTROSCOPY OF COBINAMIDES IN THE GAS PHASE: CLUES TO THE DESIGN OF VITAMIN B12

Chen, Peter

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7053.pdf
RG05_1.pptx

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https://hdl.handle.net/2142/122566

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Title
CIVP SPECTROSCOPY OF COBINAMIDES IN THE GAS PHASE: CLUES TO THE DESIGN OF VITAMIN B12
Author(s)
Chen, Peter
Contributor(s)
  • Gorbachev, Vladimir
  • Tsybizova, Alexandra
Issue Date
2023-06-22
Keyword(s)
Mini-symposium: Spectroscopy with Cryogenic Ion Traps
Abstract
Alkyl and aryl cobinamides are close relatives to adenosylcobalamine, vitamin B12, which is an essential cofactor for a large number of enzymatic transformations. We report gas-phase investigations of the Co-C bond strength by means of energy-resolved collision-induced dissociation experiments, which found unexpected discrepancies to predictions made by dispersion-corrected DFT. Attempted resolution of the discrepancies led us to further cobinamide derivatives, whose ion spectroscopy provide key information on the gas-phase structure of these large molecules (ca. 150 atoms). The structural considerations lead to a hypothesis for the mechanism of control and regulation of vitamin B12 in the enzymatic reactions.
Publisher
International Symposium on Molecular Spectroscopy
Type of Resource
Text
Genre of Resource
Conference Paper / Presentation
Language
eng
Handle URL
https://hdl.handle.net/2142/122566
DOI
https://doi.org/10.15278/isms.2023.7053

Owning Collections

Abstracts & Presentations - 2023 International Symposium on Molecular Spectroscopy PRIMARY