CIVP SPECTROSCOPY OF COBINAMIDES IN THE GAS PHASE: CLUES TO THE DESIGN OF VITAMIN B12

Chen, Peter

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Description

Title

CIVP SPECTROSCOPY OF COBINAMIDES IN THE GAS PHASE: CLUES TO THE DESIGN OF VITAMIN B12

Author(s)

Chen, Peter

Contributor(s)

• Gorbachev, Vladimir
• Tsybizova, Alexandra

Issue Date

2023-06-22

Keyword(s)

Mini-symposium: Spectroscopy with Cryogenic Ion Traps

Abstract

Alkyl and aryl cobinamides are close relatives to adenosylcobalamine, vitamin B12, which is an essential cofactor for a large number of enzymatic transformations. We report gas-phase investigations of the Co-C bond strength by means of energy-resolved collision-induced dissociation experiments, which found unexpected discrepancies to predictions made by dispersion-corrected DFT. Attempted resolution of the discrepancies led us to further cobinamide derivatives, whose ion spectroscopy provide key information on the gas-phase structure of these large molecules (ca. 150 atoms). The structural considerations lead to a hypothesis for the mechanism of control and regulation of vitamin B12 in the enzymatic reactions.

Publisher

International Symposium on Molecular Spectroscopy

Type of Resource

Text

Language

eng

Handle URL

https://hdl.handle.net/2142/122566

DOI

https://doi.org/10.15278/isms.2023.7053

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