Broadband Microwave 3-wave Mixing: Assignment-free Chirality Detection In Unknown Samples

Koumarianou, Greta

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https://hdl.handle.net/2142/116497 Copy

Description

Title

Broadband Microwave 3-wave Mixing: Assignment-free Chirality Detection In Unknown Samples

Author(s)

Koumarianou, Greta

Contributor(s)

• Patterson, David
• Satterthwaite, Lincoln
• Wang, Irene

Issue Date

2022-06-21

Keyword(s)

Chirality and stereochemistry

Abstract

Straightforward identification of chiral molecules in multi-component mixtures of unknown composition is extremely challenging. Current spectrometric and chromatographic methods cannot unambiguously identify components while the state of the art spectroscopic methods are limited by the difficult and time-consuming task of spectral assignment. Here, we introduce a highly sensitive generalized version of microwave three-wave mixing that uses broad-spectrum fields to detect chiral molecules in enantiomeric excess without any prior chemical knowledge of the sample. This method does not require spectral assignment as a necessary step to extract information out of a spectrum. We demonstrate our method by recording three-wave mixing spectra of multi-component samples that provide direct evidence of enantiomeric excess. Our method opens up new capabilities in ultrasensitive phase-coherent spectroscopic detection that can be applied for chiral detection in real-life mixtures, raw products of chemical reactions and difficult to assign novel exotic species.

Publisher

International Symposium on Molecular Spectroscopy

Type of Resource

text

Language

eng

Handle URL

https://hdl.handle.net/2142/116497

DOI

https://doi.org/10.15278/isms.2022.TE05

Copyright and License Information

Copyright 2022 held by the authors

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