Ultrasound Peeks Through the Skull

Zhao, Shensheng

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https://hdl.handle.net/2142/114310 Copy

Description

Title

Ultrasound Peeks Through the Skull

Author(s)

Zhao, Shensheng

Issue Date

2022

Keyword(s)

ECE

Abstract

The brain takes a small part of the body weight, but a striking 15 percent of the total blood pumps out from the heart to maintain oxygen and nutrition. Cerebral circulation, the blood flow in the brain, is essential for a healthy brain's function. When this circulation is impaired, oxygen and nutrition cannot reach, the brain can become damaged. Life-threatening stroke happens when the flow is blocked; coma and seizures occur when the flow is slow and oxygen is deprived. To date, available medical imaging technologies that can image cerebral circulation in detail are limited. We developed a super-resolution ultrasound imaging technique augmented by machine learning to reveal the detail of cerebral circulation in a mouse brain. Ultrasound imaging is the most widely deployed imaging modality. However, clinical ultrasound imaging systems cannot resolve the micron-sized blood vessels because of the physical limit of ultrasound focus. In addition, the skull can also distort the ultrasound signals and significantly degrade the imaging quality, which oftentimes requires removing the skull before imaging. Our imaging technique is enhanced by deep-learning and breaks the aforementioned fundamental limitations to image the cerebral circulation inside the micro blood vessels of a live mouse through the intact skull.

Type of Resource

• Text
• Image

Language

eng

Permalink

http://hdl.handle.net/2142/114310

Copyright and License Information

Copyright 2022 Shensheng Zhao

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