Confocal Imaging of GLDC Protein Localization in a Schizophrenia Mouse Model

Horner, Jenna

Permalink

https://hdl.handle.net/2142/114212 Copy

Description

Title

Confocal Imaging of GLDC Protein Localization in a Schizophrenia Mouse Model

Author(s)

Horner, Jenna

Contributor(s)

Kambali, Maltesh

Issue Date

2022

Keyword(s)

Molecular and Cellular Biology

Abstract

Because of its wide range of positive and negative symptoms, schizophrenia has become a model disorder for many other psychoses. While the mechanism is still unknown, many theories have been developed to explain the pathophysiology of this disorder. Most schizophrenia research focuses on the neuron’s play, but drugs targeting these structures have had little success. We decided to focus on astrocytes (shown as light green astral cells), cells that play a key role in regulating the environment around the neurons. Changes in these environments can lead to regulatory effects on the neurons causing downstream consequences, like changes in neuronal morphology and gene expression. This image was taken with confocal microscopy and provides a nice visual of the mouse hippocampus and the localization of cells (blue), astrocytes (light green), and GLDC (red) expression. Copy number variants of GLDC have been identified in related schizophrenia patients and results of behavioral analysis and biochemical tests revealed that the GLDC gene plays an important role in the pathophysiology of schizophrenia, however, due to a large number of types, it may be a rare player in all cases. This is just a small piece of a very large puzzle.

Type of Resource

• Text
• Image

Language

eng

Permalink

http://hdl.handle.net/2142/114212

Copyright and License Information

Copyright 2022 Jenna Horner

Owning Collections