Characterizing the targets of dysregulated microRNAs in colorectal cancer
Ghaffari, Saba
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https://hdl.handle.net/2142/114107
Description
Title
Characterizing the targets of dysregulated microRNAs in colorectal cancer
Author(s)
Ghaffari, Saba
Issue Date
2021-12-08
Director of Research (if dissertation) or Advisor (if thesis)
Sinha, Saurabh
Department of Study
Computer Science
Discipline
Computer Science
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
M.S.
Degree Level
Thesis
Keyword(s)
MicroRNA, Colorectal Cancer, Gene set characterization
Abstract
Dysregulated microRNAs have been largely associated with tumorigenesis and cancer invasion. Therefore, identifying their direct/indirect targets is crucial to study the cellular processes that are altered as a result of microRNA dysregulation. In this thesis, we aim to identify the targets of dysregulated microRNAs in colorectal cancer progression by adapting a network-guided gene set characterization technique in which prior biological knowledge can be utilized to find novel molecular associations. Further analysis of the targets found by our approach revealed a protein complex that has been proposed as a therapeutic target for inhibiting colorectal cancer in recent studies.
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