Atomically thin solid-state nanopore field-effect transistors for single-molecule sensing

Athreya, Nagendra Bala Murali

Permalink

https://hdl.handle.net/2142/114052 Copy

Description

Title

Atomically thin solid-state nanopore field-effect transistors for single-molecule sensing

Author(s)

Athreya, Nagendra Bala Murali

Issue Date

2021-11-03

Director of Research (if dissertation) or Advisor (if thesis)

Leburton, Jean-Pierre

Doctoral Committee Chair(s)

Leburton, Jean-Pierre

Committee Member(s)

• Radenovic, Aleksandra
• Milenkovic, Olgica
• Vlasov, Yurii

Department of Study

Electrical & Computer Eng

Discipline

Electrical & Computer Engr

Degree Granting Institution

University of Illinois at Urbana-Champaign

Degree Name

Ph.D.

Degree Level

Dissertation

Keyword(s)

• solid-state nanopores
• two-dimensional materials
• molecular dynamics
• electronic transport
• biosensors

Abstract

Solid-state nanopores have emerged as promising replacement candidates for single-molecule sensing over biological nanopores due to their chemical and mechanical robustness. In this context, two-dimensional solid-state materials such as graphene and MoS2 have gained much interest for ultra-fast and reliable sensing because of their atom size thickness that anticipates excellent spatial resolution and their electrical responsivity that enables sensing in-plane electron current modulated by the molecule translocating through the pore, simultaneously with ionic blockade current. This dissertation focuses on the development and implementation of a comprehensive computational model for atomically thin solid-state nanopore FETs applied toward single bio-molecule sensing. The developed software pipeline combines all-atom molecular dynamics simulations with electron transport modeling in semiconducting 2D membranes and statistical signal processing to analyze the detailed interaction between biomolecules and solid-state nanopore membranes. Various scalable FET architectures are explored in efforts to improve the sensor signal quality and bio-molecule detection capabilities. The validation of the device designs and methodology is illustrated with some of the important biomedical applications such as DNA sensing, epigenetic detection of DNA methylation, and identification of single-stranded breaks in dsDNA.

Graduation Semester

2021-12

Type of Resource

Thesis

Permalink

http://hdl.handle.net/2142/114052

Copyright and License Information

Copyright 2021 Nagendra Bala Murali Athreya

Owning Collections