Atomically thin solid-state nanopore field-effect transistors for single-molecule sensing
Athreya, Nagendra Bala Murali
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https://hdl.handle.net/2142/114052
Description
Title
Atomically thin solid-state nanopore field-effect transistors for single-molecule sensing
Author(s)
Athreya, Nagendra Bala Murali
Issue Date
2021-11-03
Director of Research (if dissertation) or Advisor (if thesis)
Leburton, Jean-Pierre
Doctoral Committee Chair(s)
Leburton, Jean-Pierre
Committee Member(s)
Radenovic, Aleksandra
Milenkovic, Olgica
Vlasov, Yurii
Department of Study
Electrical & Computer Eng
Discipline
Electrical & Computer Engr
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Date of Ingest
2022-04-29T21:58:19Z
Keyword(s)
Engineering
Language
eng
Abstract
Solid-state nanopores have emerged as promising replacement candidates for single-molecule sensing over biological nanopores due to their chemical and mechanical robustness. In this context, two-dimensional solid-state materials such as graphene and MoS2 have gained much interest for ultra-fast and reliable sensing because of their atom size thickness that anticipates excellent spatial resolution and their electrical responsivity that enables sensing in-plane electron current modulated by the molecule translocating through the pore, simultaneously with ionic blockade current. This dissertation focuses on the development and implementation of a comprehensive computational model for atomically thin solid-state nanopore FETs applied toward single bio-molecule sensing. The developed software pipeline combines all-atom molecular dynamics simulations with electron transport modeling in semiconducting 2D membranes and statistical signal processing to analyze the detailed interaction between biomolecules and solid-state nanopore membranes. Various scalable FET architectures are explored in efforts to improve the sensor signal quality and bio-molecule detection capabilities. The validation of the device designs and methodology is illustrated with some of the important biomedical applications such as DNA sensing, epigenetic detection of DNA methylation, and identification of single-stranded breaks in dsDNA.
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