Micro-particles Immunoassays For Early Detection Of Ovarian Cancer Using Laser Induced Breakdown Spectroscopy.

Karunanithy, Robinson

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https://hdl.handle.net/2142/111095 Copy

Description

Title

Micro-particles Immunoassays For Early Detection Of Ovarian Cancer Using Laser Induced Breakdown Spectroscopy.

Author(s)

Karunanithy, Robinson

Contributor(s)

• Holland, Torrey E.
• Sivakumar, P

Issue Date

2021-06-24

Keyword(s)

Spectroscopy as an analytical tool

Abstract

Detecting cancer cells before any symptoms appear is essential for successful treatment, especially for epithelial ovarian cancer (EOC) with few or no symptoms at the early stages. Although there are methods that have been developed to identify the cancer cells, scientists are looking for other novel promising methods to detect that early stage, also cheap and user-friendly. Here, we cross-link elemental particles to a specific functional group of the targeted biomolecules based on a covalent and non-covalent linking chemistry to improve the sensitivity and the selectivity of biomarker detection. In this presentation, we look into the sandwich type of micro-particle immunoassay with pair of Fe3O4 and silicon micro-particles used for highly-selective detection of specific cancer antigen human epididymis protein-4 (HE4) in which U.S. Food and Drug Administration (FDA) accepted recently as a biomarker for monitoring EOC patients. The cancer biomarkers are quantified via detecting the silicon using Laser-induced breakdown spectroscopy (LIBS).

Publisher

International Symposium on Molecular Spectroscopy

Type of Resource

Text

Language

eng

Permalink

http://hdl.handle.net/2142/111095

DOI

10.15278/isms.2021.RF01

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