Is It Chiral?towards Identifying Chirality In Unknown Samples Without Prior Spectral Assignment.

Koumarianou, Greta

Permalink

https://hdl.handle.net/2142/111013 Copy

Description

Title

Is It Chiral?towards Identifying Chirality In Unknown Samples Without Prior Spectral Assignment.

Author(s)

Koumarianou, Greta

Contributor(s)

• Patterson, David
• Wang, Irene
• Satterthwaite, Lincoln

Issue Date

2021-06-25

Keyword(s)

Spectroscopy as an analytical tool

Abstract

Current spectroscopic methods \footnote{Sérgio R. Domingos et al. ,Sensing Chirality with Rotational Spectroscopy Annual Review of Physical Chemistry 69:1, 499-519 (2018).}\textsuperscript{,}\footnote{ Nafie, L. A.; Dukor, R. K.; Freedman, T. B. Handbook of Vibrational Spectroscopy: Vibrational Circular Dichroism; Wiley Online Library, 2006.}can only detect and quantify chirality if the molecular composition of the sample has been determined. Therefore, before extracting enantiomeric information from a spectrum of an unknown sample, one needs to compare it to previously measured spectra, or to simulated spectra generated with previously determined rotational constants. We describe new developments towards an updated version of the microwave three-wave mixing technique (M3WM)\footnote{Patterson, D. Et al , Enantiomer-specific detection of chiral molecules via microwave spectroscopy. Nature 497, 475–477 (2013).} in a buffer gas cell, that can unambiguously identify the presence of chiral species in an unknown sample with no need for prior spectral assignment or knowledge of the sample composition. This work combines the established sensitivity of 3WM in a buffer gas cell in determining enantiomeric information with broadband microwave fields, and an optimized sample input, and it opens up new directions in chirality detection towards real-life molecular samples and complicated mixtures.

Publisher

International Symposium on Molecular Spectroscopy

Type of Resource

Text

Language

eng

Permalink

http://hdl.handle.net/2142/111013

DOI

10.15278/isms.2021.FF04

Owning Collections