Functional particles for controlled release and cell surface engineering

Hong, Yu-Tong

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https://hdl.handle.net/2142/110815 Copy

Description

Title

Functional particles for controlled release and cell surface engineering

Author(s)

Hong, Yu-Tong

Issue Date

2021-04-19

Director of Research (if dissertation) or Advisor (if thesis)

Kong, Hyunjoon

Doctoral Committee Chair(s)

Kong, Hyunjoon

Committee Member(s)

• Kraft, Mary L
• Rogers, Simon A
• Boppart, Marni

Department of Study

Chemical & Biomolecular Engr

Discipline

Chemical Engineering

Degree Granting Institution

University of Illinois at Urbana-Champaign

Degree Name

Ph.D.

Degree Level

Dissertation

Keyword(s)

• Nanoparticle
• Stem Cell Engineering
• Controlled Release, Surface Modification
• Biological Gel

Abstract

Engineered polymer vesicles (polymersome) have emerged as the new generation of molecular and cell carriers for a series of biomedical applications. These polymer vesicles typically present as hollow spheres that contain a hydrophilic core surrounded by a hydrophobic membrane, each of which can be loaded with a wide array of small and large molecules of interest. With the capacity to engineer and compartmentalize the properties of these particles, they can be tailored with unique design specifics to meet different applications. In this regard, the overall goal of my thesis research is to construct a functional polymersome system by implementing stimuli-responsiveness and surface modification to overcome various biological challenges. Chapter 2 demonstrates a stimuli-responsive particle with an enhanced release profile as a new formulation pathway to assemble the hemostatic fibrin-based matrix. Chapter 3 presents a polymersome-based cell adherent nanostimulator for enhanced stem cell paracrine factor secretion. I further demonstrated applications of these particle platforms in the treatment of hindlimb ischemia associate with chronic kidney disease (Chapter 4) and the delivery of CD44-binding particles for enhanced retention in aged mice associated with Alzheimer’s disease (Chapter 5). Overall, these studies present a deeper understanding of how to incorporate engineering strategies to construct functional hemostatic gelators and nanostimulator to enhance the biological efficacy of molecular and cell therapies.

Graduation Semester

2021-05

Type of Resource

Thesis

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http://hdl.handle.net/2142/110815

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