Inactivation of adenovirus serotype 41 with monochloramine

Shi, Yuehao

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https://hdl.handle.net/2142/109634 Copy

Description

Title

Inactivation of adenovirus serotype 41 with monochloramine

Author(s)

Shi, Yuehao

Issue Date

2020-12-10

Director of Research (if dissertation) or Advisor (if thesis)

Mariñas, Benito J.

Department of Study

Civil & Environmental Eng

Discipline

Environ Engr in Civil Engr

Degree Granting Institution

University of Illinois at Urbana-Champaign

Degree Name

M.S.

Degree Level

Thesis

Keyword(s)

• Adenovirus
• Monochloramine
• Inactivation

Abstract

Waterborne pathogens remain a top concern in drinking water safety. Nealy 1,000 children die worldwide each day because of preventable diseases caused by a lack of safe water and sanitation. Human Adenovirus (HAdV) is a viral pathogen that persists in contaminated water and is commonly found to cause diarrhea worldwide. The United States Environmental Protection Agency has included HAdV in the Drinking Water Contaminant Candidate List 4 for potential regulation evaluation. Drinking water disinfection is an effective way to reduce waterborne pathogens, including HAdV. However, some serotypes of HAdV are highly resistant to monochloramine, which is a commonly used disinfectant in drinking water facilities and distribution systems worldwide. At the same time, due to the difficulty of culturing enteric HAdV on common cell culture methods, the inactivation kinetics of enteric HAdV with monochloramine has not been fully characterized. The present study focuses on investigating the inactivation of enteric HAdV serotype 41, known to cause gastrointestinal disease, with monochloramine. Inactivation experiments were performed at temperatures of 5, 15, and 30°C, pH of 6, 8, and 10, monochloramine concentration of 10, 50, and 100mgCl2/L, and varying initial infectious virus concentration, and N/Cl ratio (molar ration greater than one in all cases). The data showed that higher temperature, lower pH, and lower initial virus concentration resulted in a higher inactivation rate. While the N/Cl ratio did not affect the inactivation kinetics, the effect of monochloramine concentration was inconclusive.

Graduation Semester

2020-12

Type of Resource

Thesis

Permalink

http://hdl.handle.net/2142/109634

Copyright and License Information

Copyright 2020 Yuehao Shi

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