Multimodal imaging monitoring of key physiological changes of peripheral arterial disease

Medina Almora, Denise

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https://hdl.handle.net/2142/108724 Copy

Description

Title

Multimodal imaging monitoring of key physiological changes of peripheral arterial disease

Author(s)

Medina Almora, Denise

Issue Date

2020-07-23

Director of Research (if dissertation) or Advisor (if thesis)

Dobrucki, Wawrzyniec L

Department of Study

Bioengineering

Discipline

Bioengineering

Degree Granting Institution

University of Illinois at Urbana-Champaign

Degree Name

M.S.

Degree Level

Thesis

Keyword(s)

peripheral arterial disease, angiogenesis, perfusion, diabetes, imaging, multimodal imaging.

Abstract

Peripheral Arterial Disease (PAD) limits blood flow to the lower extremities, causes functional impairment, and in extreme cases, can lead to amputation. While PAD is widely studied, there is still a large gap between preclinical research and clinical translation. This is due in part to the lack of research standardization in preclinical studies, an inadequate resemblance of the animals’ model to the actual disease in humans, and the complexity of the disease’s mechanisms. In this project, we utilized a type I diabetic mice model to establish a working platform that allows us and other researchers and scientists to standardize the preclinical animal studies of PAD. Within this platform, we will highlight critical physiological events that we term “landmarks.” To define these landmarks, we use a multimodal imaging approach starting with Laser Speckle Contrast Imaging (LSCI) and Power Doppler ultrasound for perfusion (superficial and deep tissue, respectively); followed by fluorescent imaging of hypoxia and imaging both angiogenesis and metabolism using molecular PET probes. Briefly, we found that building such a multimodal imaging approach allows us to understand vascular recovery in a holistic matter. However, most importantly, with this method, we will be able to determine the changes in the “landmarks” following the therapeutic intervention.

Graduation Semester

2020-08

Type of Resource

Thesis

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http://hdl.handle.net/2142/108724

Copyright and License Information

Copyright 2020 by Denise Medina Almora. All rights reserved.

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