Micro-particles immunoassays for early detection of ovarian cancer using laser based spectroscopy.
Karunanithy, Robinson
Loading…
Permalink
https://hdl.handle.net/2142/107621
Description
Title
Micro-particles immunoassays for early detection of ovarian cancer using laser based spectroscopy.
Author(s)
Karunanithy, Robinson
Contributor(s)
Holland, Torrey E.
Sivakumar, P.
Issue Date
2020-06-26
Keyword(s)
Spectroscopy as an analytical tool
Abstract
Detecting cancer cells before any symptoms appear is essential for successful treatment, especially for epithelial ovarian cancer (EOC) with few or no symptoms at the early stages. Although there are methods that have been developed to identify the cancer cells, scientists are looking for other novel promising methods to detect that early stage, also cheap and user-friendly. Here, we cross-link elemental particles to a specific functional group of the targeted biomolecules based on a covalent and non-covalent linking chemistry to improve the sensitivity and the selectivity of biomarker detection. In this presentation, we look into the sandwich type of micro-particle immunoassay with pair of Fe3O4 and silicon micro-particles used for highly-selective detection of specific cancer antigen human epididymis protein-4 (HE4) in which U.S. Food and Drug Administration (FDA) accepted recently as a biomarker for monitoring EOC patients. The cancer biomarkers are quantified via detecting the silicon using Laser-induced breakdown spectroscopy (LIBS).
Use this login method if you
don't
have an
@illinois.edu
email address.
(Oops, I do have one)
IDEALS migrated to a new platform on June 23, 2022. If you created
your account prior to this date, you will have to reset your password
using the forgot-password link below.
