Pirouetting Protein

Pant, Shashank

Permalink

https://hdl.handle.net/2142/106843 Copy

Description

Title

Pirouetting Protein

Author(s)

Pant, Shashank

Issue Date

2020

Keyword(s)

Biophysics and Quantitative Biology

Abstract

Lipid-dependent membrane binding of a PH domain, an archetypal membrane binding domain, is captured using advanced molecular dynamics simulations. A PIP3 lipid needed for binding of the PH domain is shown in vdW representation (carbon atoms shown in yellow), while the surrounding heterogenous plasma membrane is represented in green and grey lines respectively. The bound state of the protein with key residues coordinating the headgroup of PIP3 are shown on the left, while a number of solution states of the protein are shown in a lower resolution- middle and right. The binding free energy profile calculated for the process is drawn clearly, showing the position of the bound state as a minimum energy state, which is relatively stable compared to the solution phase.

Type of Resource

• text
• still image

Permalink

http://hdl.handle.net/2142/106843

Copyright and License Information

Copyright 2020 Shashank Pant

Owning Collections