University of Illinois Urbana-Champaign

Towards extending coarse-grained circuit-host modeling to complex environments

Sickle, Jordan

Content Files
SICKLE-THESIS-2019.pdf

Permalink

https://hdl.handle.net/2142/106484

Description

Title
Towards extending coarse-grained circuit-host modeling to complex environments
Author(s)
Sickle, Jordan
Issue Date
2019-12-12
Director of Research (if dissertation) or Advisor (if thesis)
Lu, Ting
Department of Study
School of Molecular & Cell Bio
Discipline
Biophysics & Quant Biology
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
M.S.
Degree Level
Thesis
Date of Ingest
2020-03-02T22:38:56Z
Keyword(s)
  • Synthetic Biology
  • Mathematical Modeling
Abstract
Over the last two decades, synthetic biology has emerged as a critical toolset for genetic engineering. Synthetic gene circuits have been engineered for a variety of uses from functional modules to increasing biosynthetic yield. After decades of showing their potential in labs, synthetic circuits are about to make the leap into complex environments. Recent advances have shown that a mechanistic, coarse-grained approach can give fundamental insight into how synthetic circuits interact with their host cells, though how this model can be applied in complex environments remains an open question. In this thesis, I will discuss how an extension of this coarse-grained model can describe circuit behavior in complex environments through mechanistic modeling of chloramphenicol and nutrient stress.
Graduation Semester
2019-12
Type of Resource
text
Permalink
http://hdl.handle.net/2142/106484
Copyright and License Information
Copyright 2019 Jordan Sickle

Owning Collections

Graduate Dissertations and Theses at Illinois PRIMARY
Graduate Theses and Dissertations at Illinois
Dissertations and Theses - Biophysics and Quantitative Biology