Tunable Luminescent Carbon Nanospheres with Well-Defined Nanoscale Chemistry for Synchronized Imaging and Therapy

Scott, John W.

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https://hdl.handle.net/2142/106044 Copy

Description

Title

Tunable Luminescent Carbon Nanospheres with Well-Defined Nanoscale Chemistry for Synchronized Imaging and Therapy

Author(s)

Scott, John W.

Issue Date

2014

Keyword(s)

• Nantechnology
• Imaging

Abstract

Major advances in the medical field have shortened surgical recovery times from weeks to only a few days. Reducing the size of the surgical incision is one key to this breakthrough. However, to decrease the incision size, the diagnostic and therapeutic tools must become smaller too. The theranostic nanoplatform was developed to address that issue, but to date, several methodologies have been developed with materials that have low biodegradability and biocompatibility, and thus cannot be clinically tested. In addition, many require awkward synthesis or tedious purification processes, making them difficult to scale up to the large quantities needed for clinical use. To be effective, theranostic nanoplatforms must target a specific cell, have controlled drug release, and have robust sensors or imaging functionality to overcome physical barriers to in vivo diagnostics and therapy. To develop a theronostic nanoplatform that is viable for clinical testing, ISTC’s senior chemist John Scott partnered with University of Illinois researchers to develop a tunable luminescent carbon nanoparticles (LCN) that could be used as a theronostic nanoplatform that has both optical signaling and pharmacokinetic properties. Results published in Mukherjee, P., Misra, S.K., Gryka, M.C., Chang, H.‐H., Tiwari, S., Wilson, W.L., Scott, J.W., Bhargava, R. and Pan, D. (2015), Tunable Luminescent Carbon Nanospheres with Well‐Defined Nanoscale Chemistry for Synchronized Imaging and Therapy. Small, 11: 4691-4703. doi:10.1002/smll.201500728

Publisher

Champaign, IL : Illinois Sustainable Technology Center

Series/Report Name or Number

Pollutants -- PPCPs in the Environment

Type of Resource

text

Language

en

Permalink

• https://doi.org/10.1002/smll.201500728
• http://hdl.handle.net/2142/106044

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