University of Illinois Urbana-Champaign

Discrete frequency mid-infrared spectroscopic imaging using quantum cascade lasers

Yeh, Kevin

Content Files
YEH-DISSERTATION-2019.pdf

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https://hdl.handle.net/2142/105846

Description

Title
Discrete frequency mid-infrared spectroscopic imaging using quantum cascade lasers
Author(s)
Yeh, Kevin
Issue Date
2019-07-12
Director of Research (if dissertation) or Advisor (if thesis)
Bhargava, Rohit
Doctoral Committee Chair(s)
Bhargava, Rohit
Committee Member(s)
  • Irudayaraj, Joseph Maria Kumar
  • Pan, Dipanjan
  • Kajdacsy-Balla, Andre
Department of Study
Bioengineering
Discipline
Bioengineering
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Date of Ingest
2019-11-26T20:56:41Z
Keyword(s)
Chemical imaging, infrared spectroscopy, quantum cascade laser
Abstract
Infrared (IR) spectroscopic imaging is an analytical technique that directly images the spatial distribution of chemical components within a sample in the absence of external contrast agents. This is especially advantageous with biological samples where the mid to far-infrared wavelength range corresponds with the vibrational modes of functional groups in many organic molecules. In recent years, the technology enabling discrete frequency infrared (DFIR) spectroscopic microscopy has undergone many substantive changes due to rapid developments in quantum cascade lasers (QCL) in terms of their output power, beam stability, and wavelength tuning range. In this dissertation, we present the research and development of several state-of-the-art microscopy systems that have advanced what was previously possible with industry standard instruments. Through drastic improvements in imaging speed and resolution, as well as reductions in noise and aberrations, our systems serve as a flexible platform with capabilities that open new avenues for research and clinical interests.
Graduation Semester
2019-08
Type of Resource
text
Permalink
http://hdl.handle.net/2142/105846
Copyright and License Information
Copyright 2019 Kevin Yeh

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