University of Illinois Urbana-Champaign

An investigation of the effects of diet on the gastrointestinal microbiota, inflammation, and metabolic endotoxemia in adults

Bailey, Melisa Ann

Content Files
BAILEY-THESIS-2019.pdf

Permalink

https://hdl.handle.net/2142/105268

Description

Title
An investigation of the effects of diet on the gastrointestinal microbiota, inflammation, and metabolic endotoxemia in adults
Author(s)
Bailey, Melisa Ann
Issue Date
2019-04-26
Director of Research (if dissertation) or Advisor (if thesis)
Holscher, Hannah D.
Doctoral Committee Chair(s)
Donovan, Sharon
Committee Member(s)
  • Khan, Naiman
  • Swanson, Kelly
Department of Study
Nutritional Sciences
Discipline
Nutritional Sciences
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
M.S.
Degree Level
Thesis
Date of Ingest
2019-08-23T20:48:27Z
Keyword(s)
metabolic endotoxemia, inflammation, microbiome, microbiota, dietary fiber
Abstract
As rates of overweight and obesity, and their related comorbid conditions continue to rise, the need to understand the mechanisms of obesity and metabolic disease and recommend strategies for prevention and treatment has never been greater. Dietary strategies for weight loss and weight maintenance offer the greatest opportunity to provide low-cost, safe, and universally available treatments compared to pharmaceutical and surgical interventions. Some dietary patterns, like the Mediterranean diet pattern, are widely known for their promotion of metabolic and whole-body health. However, a complete understanding of the mechanisms by which foods associated with the Mediterranean diet pattern contribute to health is lacking. The Mediterranean diet pattern is characterized by a high intake of fruits, vegetables, whole grains, legumes, and nuts; moderate consumption of seafood and red wine; and low consumption of the red and processed meats and sugar-sweetened beverages common in the Western diet pattern. Dietary fiber, a nutrient far more abundant in a Mediterranean diet pattern than a Western pattern, decreases inflammation through a complex web of physiological interactions including the modulation of the gastrointestinal (GI) microbiota and bacterial fermentation end-products, GI barrier structure and function, and the enterohepatic circulation of bile acids. One of the mechanisms by which consumption of dietary fibers may contribute to decreased whole-body inflammation is through the prevention of metabolic endotoxemia, defined as a 2- to 3- fold increase in the circulating concentrations of the pathogen associated molecular pattern lipopolysaccharide (LPS). As the largest reservoir of LPS in the body, the GI microbiota represents an under-investigated frontier of human metabolic health. It was the aim of this thesis to investigate the effects of diet on the GI microbiota, metabolic endotoxemia, inflammation, and metabolic disease risk in adults of varying weight status.
Graduation Semester
2019-05
Type of Resource
text
Permalink
http://hdl.handle.net/2142/105268
Copyright and License Information
© 2019 Melisa A. Bailey

Owning Collections

Graduate Dissertations and Theses at Illinois PRIMARY
Graduate Theses and Dissertations at Illinois
Dissertations and Theses - Nutritional Sciences