Literature-based discovery of known and potential new mechanisms for relating the status of cholesterol to the progression of breast cancer
Wang, Yu
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https://hdl.handle.net/2142/104825
Description
Title
Literature-based discovery of known and potential new mechanisms for relating the status of cholesterol to the progression of breast cancer
Author(s)
Wang, Yu
Issue Date
2019-04-17
Director of Research (if dissertation) or Advisor (if thesis)
Torvik, Vetle I.
Nelson, Erik Russell
Department of Study
Information Sciences
Discipline
Bioinformatics
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
M.S.
Degree Level
Thesis
Keyword(s)
Literature-based discovery
literature review
breast cancer
cholesterol
mechanisms
Abstract
Breast cancer has been studied for a long period of time and from a variety of perspectives in order to understand its pathogeny. The pathogeny of breast cancer can be classified into two groups: hereditary and spontaneous. Although cancer in general is considered a genetic disease, spontaneous factors are responsible for most of the pathogeny of breast cancer. In other words, breast cancer is more likely to be caused and deteriorated by the dysfunction of a physical molecule than be caused by germline mutation directly. Interestingly, cholesterol, as one of those molecules, has been discovered to correlate with breast cancer risk. However, the mechanisms of how cholesterol helps breast cancer progression are not thoroughly understood. As a result, this study aims to study known and discover potential new mechanisms regarding to the correlation of cholesterol and breast cancer progression using literature review and literature-based discovery. The known mechanisms are further classified into four groups: cholesterol membrane content, transport of cholesterol, cholesterol metabolites, and other. The potential mechanisms, which are intended to provide potential new treatments, have been identified and checked for feasibility by an expert.
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