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https://hdl.handle.net/2142/104032
Description
Title
Subspace approach to magnetic resonance imaging
Author(s)
Park, Somie
Contributor(s)
Liang, Zhi-Pei
Issue Date
2019-05
Keyword(s)
MRSI
MRI
partial separability
subspace approach
Abstract
Magnetic resonance spectroscopic imaging (MRSI) is an imaging method that uses the same principles as
MRI and detects signals from water, lipids, brain metabolites and neurotransmitters. However, unlike
MRI, it gives a time sequence of images so that each voxel gives a frequency spectrum where certain
peaks correspond to different metabolites. This gives more information than MRI and has applications in
cancer imaging and detection/characterization of disease. However, long data acquisition time, poor
spatial resolution, and low SNR have hindered clinical usage of MRSI. The subspace approach was
developed by Professor Liang’s research group that combats these challenges. The subspace approach
takes advantage of that the desired spatial-temporal function of the metabolite signal can be modeled
by partially separable functions. With regards to data acquisition, the subspace approach has sparse
temporal sampling and extended k-space coverage which allows for accelerated data acquisition. The
subspace approach reduces the number of unknowns and enables the accurate reconstruction of high
resolution spatiospectral function from sparse and noisy data. Using this approach results in faster scan
times while still retaining the useful metabolic information.
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