Unraveling cell nucleus structure

Liu, Wenjie

Permalink

https://hdl.handle.net/2142/103707 Copy

Description

Title

Unraveling cell nucleus structure

Author(s)

Liu, Wenjie

Issue Date

2019

Keyword(s)

Bioengineering

Abstract

Cell nucleus stores our genetic information within DNA. It is estimated that about 3.2 billion bases of DNA (around 1 m in length) reside in the nucleus, which is packaged as chromatins. The local structure of chromatin lies the blueprint that dictates everything a cell does. Such small and fascinating structure was not able to be fully resolved under microscope several years ago. With recent advance in super-resolution imaging, this becomes possible. My research looks at those tiny structures at single cell level beyond the diffraction limit. I investigated the dynamic of nucleus structure on cell function with environmental pollution. We discovered that Perfluorooctanoic acid (coating material for non-stick pot) could change the heterochromatin structure, resulting in cancerous cell fate.

Type of Resource

• text
• image

Permalink

http://hdl.handle.net/2142/103707

Copyright and License Information

Copyright 2019 Wenjie Liu

Owning Collections