Phase-controlled dual-comb coherent anti-stokes raman spectroscopic imaging

Wei, Haoyun

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https://hdl.handle.net/2142/100618 Copy

Description

Title

Phase-controlled dual-comb coherent anti-stokes raman spectroscopic imaging

Author(s)

Wei, Haoyun

Contributor(s)

• Li, Yan
• Wu, Tao
• Chen, Kun

Issue Date

2018-06-19

Keyword(s)

Mini-symposium: Frequency-Comb Spectroscopy

Abstract

Coherent Raman microscopy can intrinsically enable label-free imaging by measuring vibrational spectra of biomolecules. Nevertheless, trade-off between high chemical-specificity and high imaging-speed currently exists in transition from spectroscopy to spectroscopic imaging when capturing dynamics in complex living systems. Here, we present a dual-comb scheme to substantially beat this trade-off and facilitate high-resolution broadband coherent anti-Stokes Raman spectroscopic imaging by combining dual-comb asynchronous optical scanning and phase-controlled spectral focusing excitation. A rapid measurement of vibrational micro-spectroscopy on sub-microsecond scale over a spectral span 700 cm−1with solid signal-to-noise ratio provides access to well-resolved molecular signatures within the fingerprint region. We demonstrate this high-performance spectroscopic imaging for spatially inhomogeneous distributions of chemical substances. This technique offers an unprecedented route for broadband CARS imaging with hundreds of kHz spectroscopic refresh rate using available 1-GHz oscillators.

Publisher

International Symposium on Molecular Spectroscopy

Type of Resource

text

Language

eng

Permalink

http://hdl.handle.net/2142/100618

DOI

10.15278/isms.2018.TA08

Copyright and License Information

Copyright 2018 Haoyun Wei

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