Enantiomeric excess measurements using microwave three-wave mixing

Holdren, Martin S.

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https://hdl.handle.net/2142/100744 Copy

Description

Title

Enantiomeric excess measurements using microwave three-wave mixing

Author(s)

Holdren, Martin S.

Contributor(s)

• Evangelisti, Luca
• Mitchell, Brianna
• Haghtalab, Golara
• Buoniconti, Patrick
• Dittman, James
• Mayer, Kevin J.
• Wu, Arthur
• Embly, Caitlin
• Pate, Brooks

Issue Date

2018-06-19

Keyword(s)

Chirality and stereochemistry

Abstract

Microwave three-wave mixing was demonstrated in 2013 by Patterson, Schnell, and Doyle (D. Patterson, M. Schnell, and J.M Doyle, Nature 497, 475- 478 (2013)) to distinguish a pair of enantiomers by rotational spectroscopy. This is possible because the product of the three electric dipole components in the principal axis system has opposite sign for enantiomers. The three-wave measurement produces a coherent emission signal proportional to the product of the dipole moment components making it possible to distinguish enantiomers through the phase of the signal. The enantiomeric excess (EE) is then proportional to the signal amplitude. Microwave three-wave mixing experiments were performed to quantify the EE and assess the limits of low EE measurements of the molecules propylene oxide, 1,2-propanediol, and isopulegol. Challenges in these measurements will be discussed including the need for low-frequency coherence transfer pulses due to phase matching requirements in generation of the chiral signal. Other measurement issues like the possibility of off-resonance direct excitation of the chiral transition that can limit instrument performance will be described. Lastly, a test of the linearity of the three-wave mixing signals as a function of EE using isopulegol reference mixtures will be presented.

Publisher

International Symposium on Molecular Spectroscopy

Type of Resource

text

Language

eng

Permalink

http://hdl.handle.net/2142/100744

DOI

10.15278/isms.2018.TC08

Copyright and License Information

Copyright 2018 Martin S. Holdren

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