Development & testing of ultrasound enhanced prodrug microbubble drug delivery system
Patel, Rushi
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https://hdl.handle.net/2142/101741
Description
Title
Development & testing of ultrasound enhanced prodrug microbubble drug delivery system
Author(s)
Patel, Rushi
Issue Date
2018-05-07
Director of Research (if dissertation) or Advisor (if thesis)
Pan, Dipanjan
Department of Study
Bioengineering
Discipline
Bioengineering
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
M.S.
Degree Level
Thesis
Keyword(s)
Microbubbles
Drug Delivery
Abstract
Microbubble drug delivery systems vary widely in their design and. This work focused on the application of a novel microbubble system with ultrasound-mediated delivery enhancement via consumer equipment.
The work involved the creation of a novel microbubble formulation using a prodrug of Bexarotene to make the exterior layer of the microbubble. This started with development and engineering of productions schemes for stable microbubbles. Physical characterization was done to confirm production and was followed by initial in vitro testing. Results were indicative that microbubbles were formed via the protocol developed, and phantom imaging studies confirmed the enhance contrast from microbubbles for ultrasound imaging. Additionally, the in vitro tests showed enhance effectiveness in drug delivery for C32 cells through multiple assays. Demonstrating the effectiveness of using lipid type prodrugs for the creation of microbubbles and their uses for ultrasound enhanced therapy.
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