Withdraw
Loading…
The guardians of cell fate: protective mechanisms that ensure proper cell fate and patterning during imaginal disc regeneration in drosophila
Schuster, Keaton Jay
Loading…
Permalink
https://hdl.handle.net/2142/101694
Description
- Title
- The guardians of cell fate: protective mechanisms that ensure proper cell fate and patterning during imaginal disc regeneration in drosophila
- Author(s)
- Schuster, Keaton Jay
- Issue Date
- 2018-07-10
- Director of Research (if dissertation) or Advisor (if thesis)
- Smith-Bolton, Rachel K
- Doctoral Committee Chair(s)
- Stubbs, Lisa J.
- Committee Member(s)
- Mizzen, Craig
- Raetzman, Lori T.
- Department of Study
- Cell & Developmental Biology
- Discipline
- Cell and Developmental Biology
- Degree Granting Institution
- University of Illinois at Urbana-Champaign
- Degree Name
- Ph.D.
- Degree Level
- Dissertation
- Keyword(s)
- Regeneration, Cell Fate, Patterning, Drosophila
- Abstract
- Regenerating tissue must replace lost structures with cells of the proper identity and pattern in order to restore function. This thesis will describe two major insights into how patterning and cell fate is maintained and restored during the late phases of regeneration in the wing imaginal disc of Drosophila. First, the identification of taranis as a regeneration-specific patterning gene and its subsequent characterization as a factor that is required to protect the regenerating cells in the wing imaginal disc from inappropriate posterior to anterior cell fate changes that are induced by the powerful JNK signaling cascade at the wound misregulating the expression of engrailed. The other chapter will detail the identification of the pioneer transcription factor Zelda as being upstream of taranis expression during regeneration. Zelda is found to be expressed at the same place and time as Taranis, and reduction of Zelda levels results in profound anterior and posterior patterning defects. Speculation is provided suggesting that Zelda may also be essential for the large developmental transition from a program devoted to regenerative growth to the repatterning phase that allows for the restoration of cell fate and patterning genes that was lost earlier in regeneration. This work describes identification of a novel gene regulatory network essential for patterning and cell fate during regeneration.
- Graduation Semester
- 2018-08
- Type of Resource
- text
- Permalink
- http://hdl.handle.net/2142/101694
- Copyright and License Information
- Copyright 2018 Keaton Schuster
Owning Collections
Graduate Dissertations and Theses at Illinois PRIMARY
Graduate Theses and Dissertations at IllinoisManage Files
Loading…
Edit Collection Membership
Loading…
Edit Metadata
Loading…
Edit Properties
Loading…
Embargoes
Loading…