University of Illinois Urbana-Champaign

Stabilization of liposomal functional anchors by cross-linkable lipids

Smith, Cartney

Content Files
Smith_Cartney.pdf

Permalink

https://hdl.handle.net/2142/100421

Description

Title
Stabilization of liposomal functional anchors by cross-linkable lipids
Author(s)
Smith, Cartney
Issue Date
2013-07-15
Director of Research (if dissertation) or Advisor (if thesis)
Kong, Hyunjoon
Committee Member(s)
Kong, Hyunjoon
Department of Study
Chemical & Biomolecular Engr
Discipline
Chemical Engineering
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
M.S.
Degree Level
Thesis
Date of Ingest
2018-08-14T21:37:14Z
Keyword(s)
  • Cross-Linkable Lipids
  • Magnetic Resonance Imaging
  • Chitosan
  • Liposome
Abstract
Micro- and nanoparticles are designed to deliver drugs and contrast agents to their target site in a controlled manner. One of the greatest obstacles in the performance of such delivery vehicles is their stability in the presence of serum. Here we investigate a method to stabilize a class of liposomes in which lipid vesicles are modified post- fabrication through surface adsorption and anchoring. We hypothesized that the sequential adsorption of functional units followed by covalent cross-linking of the liposome would provide enhanced stability in the presence of human serum. To investigate this hypothesis, liposomes composed of diyne-containing lipids were assembled and functionalized via chitosan conjugated with a hydrophobic anchor and the magnetic resonance (MR) contrast agent, gadolinium, as a model functionality. This strategy served to stabilize the thermodynamically favorable association between liposome and modified functional chitosan. Furthermore, the chitosan-coated, cross-linked liposomes proved more effective as delivery vehicles of MR contrast agents than uncross-linked liposomes due to the reduced liposome degradation and chitosan desorption. Overall, this study demonstrates a useful method to stabilize a broad class of particles used for systemic delivery of various molecular cargos.
Graduation Semester
2013-08
Type of Resource
text
Permalink
  • http://hdl.handle.net/123456789/2295
  • http://hdl.handle.net/2142/100421
Copyright and License Information
Copyright 2013 Cartney E. Smith

Owning Collections

Graduate Dissertations and Theses at Illinois PRIMARY
Graduate Theses and Dissertations at Illinois