Happy Hearts: Associations of Maternal Depressive Symptomatology on Child Profiles of C-Reactive Protein

Majid, Danish; Inoue, Makoto; Schwingel, Andiara; Hernandez, Rosalba

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https://hdl.handle.net/2142/100408 Copy

Description

Title

Happy Hearts: Associations of Maternal Depressive Symptomatology on Child Profiles of C-Reactive Protein

Author(s)

• Majid, Danish
• Inoue, Makoto
• Schwingel, Andiara
• Hernandez, Rosalba

Contributor(s)

Aguayo, Liliana

Issue Date

2018

Keyword(s)

• Kinesiology
• Community Health
• C-Reactive Protein
• Depression
• Obesity

Abstract

Elevated concentrations of inflammatory markers in the bloodstream, such as C-reactive protein (CRP), can predict development of obesity and cardiometabolic dysfunction. Elevated CRP levels are found as early as infancy among children born to mothers with maternal depression. Little is known, however, of the intergenerational influence of maternal depression on offspring’s CRP profiles and the associated obesity risks during childhood, particularly in high-risk populations with limited resources. Cross-sectional data was collected from low-income Mexican mother-child dyads (n=97) living in central Mexico enrolled in the Family-based Intergenerational Evaluation of Salivary Telomeres and Acculturation (FIESTA) study. Mothers completed the Patient Healthcare Questionnaire (PHQ-9) to screen for depression. Body composition through bioelectrical impedance and dried blood spots were collected across all dyads. An enzyme-linked immunosorbent assay (ELISA) kit will be used to measure CRP from dried blood spots. Mothers ranged in age from 19 to 55 (M=31.29±8.42). Half the mothers were overweight (50.5%), and 23.7% met criteria for obesity, and 15.5% of mothers had elevated depressive symptoms (PHQ-9 ≥9 ). Children were between the ages of 3 to 6 years old (M=4.58±0.57). About 48.2% of children were male, 13.4% of children were overweight and 20.7% were considered obese. Results are forthcoming for CRP profiles, but we anticipate a positive association with body weight and moderation of this relationship (if any) by maternal depression status. This study has the potential to introduce preliminary evidence of the intergenerational interaction between maternal depressive symptoms and childhood CRP profiles and subsequent effect on child weight status.

Type of Resource

image

Permalink

http://hdl.handle.net/2142/100408

Sponsor(s)/Grant Number(s)

Office of Undergraduate Research

Copyright and License Information

• Copyright 2018 Danish Majid
• Copyright 2018 Makoto Inoue
• Copyright 2018 Andiara Schwingel
• Copyright 2018 Rosalba Hernandez

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