Association Between Food Allergy and Microbiome Status in 1-Year-Old Infants in STRONG Kids 2 Cohort

Qin, Yue; Wang, Mei; Dong, Ping

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https://hdl.handle.net/2142/99865 Copy

Description

Title

Association Between Food Allergy and Microbiome Status in 1-Year-Old Infants in STRONG Kids 2 Cohort

Author(s)

• Qin, Yue
• Wang, Mei
• Dong, Ping

Contributor(s)

Donovan, Sharon M.

Issue Date

2018-04

Keyword(s)

• Food Science and Human Nutrition
• Health
• Food Allergy
• Infant
• Gut Microbiome
• Strong Kids

Abstract

Objectives: The research aims to determine the association between suspected food allergy (FA) in 12-month-old infants enrolled in the STRONG kids 2 cohort and the composition of their fecal microbiome at five points in the first 12 months of age. Procedures: As part of the STRONG Kids Program 2 survey, parents are asked if their child has had any allergic reactions, sensitivity, or intolerance caused by food. If parents report their child has had any of these symptoms, the child will be classified as “infants with suspected FA”, if not, the child will be classified as “matched control” group. Parents submit stool samples of infants at 1 week, 6 weeks, 3 months, 5-7 months (1 month after the introduction to solid food) and 12 months of age. DNA will be extracted from the stool samples and the abundance of specific bacterial genera that have been associated with increased risk of food allergy in previous studies will be measured using real time quantitative PCR (RT-qPCR). Work arrangements: Most of the lab work will be conducted in Dr. Sharon Donovan’s lab in 338 Bevier Hall. The qPCR machine located in the Keck Center in the Edward R. Madigan Laboratory will also be utilized.

Type of Resource

image

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http://hdl.handle.net/2142/99865

Sponsor(s)/Grant Number(s)

ACES Undergraduate Research Award

Copyright and License Information

• Copyright 2018 Yue Qin
• Copyright 2018 Mei Wang
• Copyright 2018 Ping Dong

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