University of Illinois Urbana-Champaign

Characterization of termination patterns of layers 5 and 6 cortical neurons in the mouse inferior colliculus.

Yudintsev, Georgiy; Llano, Daniel A.

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ARO_2018_Poster_Gosha_56 by 42 in.pdf

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https://hdl.handle.net/2142/99811

Description

Title
Characterization of termination patterns of layers 5 and 6 cortical neurons in the mouse inferior colliculus.
Author(s)
  • Yudintsev, Georgiy
  • Llano, Daniel A.
Issue Date
2018
Keyword(s)
  • Corticocollicular
  • Auditory cortex
  • Inferior colliculus
Date of Ingest
2018-04-27T21:34:00Z
Abstract
Top-down modulation is thought to be one mechanism by which the brain can disambiguate sensory signals, and descending projections are believed to be the substrate through which this modulation occurs. One of such projections - the corticocollicular (CC) projection - recently garnered much attention due to its potential to alter response properties in the inferior colliculus (IC). However, the anatomical organization of this pathway remains poorly understood. Earlier we demonstrated significant heterogeneity in the distributions of layer 5 and 6 CC neurons in the cortex, with layer 6 cells spanning across a broader area of the cortex than layer 5. However, the comparison of the termination patterns from layer 5 and layer 6 neurons is yet to be made. In the present study, we used two viral approaches in Rbp4-cre mouse line to differentially express fluorescent markers in layer 5 and layer 6 corticocollicular neurons in the same animal, and later compare the distributions of their axons in all subdivisions of the IC. Using confocal microscopy, we found that both layer 5 and layer 6 CC neurons heavily projected to lateral (LC) and dorsal cortices (DC) in the ipsilateral IC, with some terminals found in the contralateral DC and ipsilateral central nucleus (CN). Additionally, layer 6 CC axons and terminals tended to be thinner and smaller on average than axons and terminals from layer 5 CC cells. These findings further suggest different functions for layer 5 and 6 CC neurons and provide a foundation for further differential optogenetic manipulations of layer 5 and 6 corticocollicular projections.
Type of Resource
other
Genre of Resource
Conference Poster
Language
en
Permalink
http://hdl.handle.net/2142/99811
Sponsor(s)/Grant Number(s)
NIDCD R01 DC013073 02
Copyright and License Information
Copyright 2018 Georgiy Yudintsev. and Daniel A. Llano

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