Director of Research (if dissertation) or Advisor (if thesis)
Leckband, Deborah
Committee Member(s)
Ha, Taekjip
Department of Study
Bioengineering
Discipline
Bioengineering
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
M.S.
Degree Level
Thesis
Keyword(s)
Cell adhesion
Abstract
The well-established dependence of cell traction forces on the compliance of supporting matrices has been attributed to levels of force exerted on components in focal contacts. Here, use of novel, force-limited nanoscale tension gauges revealed that both force and substrate deformations govern cell decision-making during initial attachment to compliant substrates. We propose a mechanical model consistent with observed behavior. Upon formation of stable cell contacts, bond tension and tether rupture govern cell attachment, spreading, and focal adhesion maturation at force levels on individual receptors predicted by prior studies.
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