Transcriptiome analysis of a migraine model

Jeong, Hyeon Soo

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https://hdl.handle.net/2142/98230 Copy

Description

Title

Transcriptiome analysis of a migraine model

Author(s)

Jeong, Hyeon Soo

Issue Date

2017-06-12

Director of Research (if dissertation) or Advisor (if thesis)

Rodriguez-Zas, Sandra Luisa

Department of Study

Animal Sciences

Discipline

Animal Sciences

Degree Granting Institution

University of Illinois at Urbana-Champaign

Degree Name

M.S.

Degree Level

Thesis

Keyword(s)

• Migraine
• Transcriptome
• Hyperalgesia
• Neuropeptides
• Transcription factor

Abstract

Migraine is a serious episodic headaches affecting more than 15% of the human population with a detrimental influence on the patients’ life and socioeconomic functioning. Although many pathophysiological and molecular mechanisms of migraine have been suggested, little is known about the molecular disruption in a chronic migraine. Here, we propose to characterize the differences of the gene expression, biological processes and pathways, and regulatory network between individuals with control and a hyperalgesia mouse model of chronic migraine. Chronic hyperalgesia was modeled using a nitroglycerin treatment. The transcriptome was characterized in the trigeminal ganglia and nucleus accumbens. Samples were sequenced using the Illumina HiSeq 4000 platform to produce paired end reads of 100 bp. Opalin, Slc32a, Cacna1b, and H2-Eb2 were among the 110 genes exhibiting significant interaction effects. The 165 genes presenting different expression patterns between the treatment and control groups included Aldh1a1 and Slc7a2. A comparative transcriptomic analysis offered insights for migraine therapies.

Graduation Semester

2017-08

Type of Resource

text

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http://hdl.handle.net/2142/98230

Copyright and License Information

Copyright 2017 Hyeon Soo Jeong

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