University of Illinois Urbana-Champaign

Development of x-ray luminescence detection system and characterization of x-ray irradiated quantum dots for image-guided x-ray photodynamic therapy

Yoon, Byung Hui

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https://hdl.handle.net/2142/97318

Description

Title
Development of x-ray luminescence detection system and characterization of x-ray irradiated quantum dots for image-guided x-ray photodynamic therapy
Author(s)
Yoon, Byung Hui
Issue Date
2017-04-11
Director of Research (if dissertation) or Advisor (if thesis)
Meng, Ling-Jian
Department of Study
Bioengineering
Discipline
Bioengineering
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
M.S.
Degree Level
Thesis
Keyword(s)
  • X-ray
  • X-ray luminescence
  • Quantum dots
  • Doped quantum dots
  • Polydimethylsiloxane (PDMS)
  • Optical phantom
  • Scintillation
  • Nanotechnology
  • Radiology
Abstract
The work in this thesis demonstrates X-ray luminescence (XL) detection system setup and XL quantification of X-ray irradiated quantum dots (QDs) to study efficiencies of X-ray photodynamic therapy (X-PDT). The XL detection system utilizes a light-sensitive electron-multiplying charge coupled device (EMCCD), a demagnifying (DM) image intensifier, and on optical lens to monitor XL signal emitted from the QDs. We used core-shell QDs and doped QDs to characterize their XL properties and absorption of X-ray photons. Along with the characterization of XL, the work eventually discusses potential applications of the system as a new biomedical theranostic modality. This study also demonstrates how well-controlled synthesis parameters of QDs such as elemental composition and dopant integration foreshow mechanisms of XL. Superimposed images of optical and XL signals are also presented to show potential fluorescence microscope imaging applications. Additionally, polydimethylsiloxane (PDMS)-based optical phantom with scattering medium was fabricated to reproduce tissue-mimicking optical property in XL computed tomography (XLCT) study.
Graduation Semester
2017-05
Type of Resource
text
Permalink
http://hdl.handle.net/2142/97318
Copyright and License Information
Copyright 2017 Byung Hui Yoon

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